Title:
PRODUCTION OF 3-PHENYL-2-AMINO-2-METHYLPROPIONIC ACID AMIDES
Document Type and Number:
Japanese Patent JPS59161341
Kind Code:
A
Abstract:
PURPOSE: 3-Phenyl-2-amino-2-methylpropionitrile is allowed to react with hydrogen peroxide to enable the production of the titled compound which is used as a synthetic intermediate of L-α-methyldopa, a hypotensor, or an industrial scale.
CONSTITUTION: The reaction between 3-phenyl-2-amino-2-methylpropionitrile of formula I (X, Y are H, halogen, lower alkyl; X, Y incorporate with a part of the benzene ring to form a 3W7 membered heterocyclic ring containing one or two oxygen atoms) and hydrogen peroxide is carried out in aqueous alcohol under basic conditions of sodium hydroxide or the like, at -5W50°C for 0.5W5hr to give the objective compound of formula II.
Inventors:
ENOMIYA TAKUJI
SHIRAISHI HIROSHI
INOUE MOTOO
SHIRAISHI HIROSHI
INOUE MOTOO
Application Number:
JP3183083A
Publication Date:
September 12, 1984
Filing Date:
March 01, 1983
Export Citation:
Assignee:
UBE INDUSTRIES
International Classes:
C07D317/60; C07C67/00; C07C231/00; C07C231/06; C07C237/20; (IPC1-7): C07C103/28; C07C103/29; C07D317/60
Previous Patent: JPS59161340
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