Title:
NOVEL MONACOLIN DERIVATIVE, ITS PREPARATION AND REMEDY FOR HYPERLIPEMIA CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPS59122483
Kind Code:
A
Abstract:
NEW MATERIAL:The compound of formula I (R1 is H or methyl; R2 is H, halogen or halogenoalkyl; R3 is H, halogen or lower alkyl; R4 is halogen, azido, OH, mercapto, etc.; R5 is H, t-butyl or trialkylsilyl; the bond denoted by the dotted line is present or absent).
USE: A remedy for hyperlipemia and a preventive for arteriosclerosis. It has excellent activity to lower the cholesterol level.
PROCESS: The compound of formula I (R5 is H) is prepared by reacting the compound of formula II (R6 is t-butyl or trialkylsilyl) with an acid (e.g. hydrogen fluoride, methanesulfonic acid, p-toluenesulfonic acid, etc.) in a solvent such as acetonitrile, methylene chloride, etc., at room temperature for several tens seconds W 12hr.
Inventors:
KUWATA BAN
ARAKAWA MORIMASA
OGI TOKIO
FUJIMOTO YASUO
ARAKAWA MORIMASA
OGI TOKIO
FUJIMOTO YASUO
Application Number:
JP22765782A
Publication Date:
July 14, 1984
Filing Date:
December 28, 1982
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO
International Classes:
C07D309/30; A61K31/35; A61K31/351; A61P3/06; (IPC1-7): A61K31/35; C07D309/30
Domestic Patent References:
| JPS56150037A | 1981-11-20 | |||
| JPS51136886A | 1976-11-26 | |||
| JPS559024A | 1980-01-22 |
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