Title:
SOFT BONE AND REPAIRING METHOD THEREOF
Document Type and Number:
Japanese Patent JPS59192364
Kind Code:
A
Abstract:
There are provided compositions for repairing defects of cartilage and bones. These are provided in gel form either as such, or embedded in natural or artificial bones. The gel comprises certain types of cells. These may be committed embryonal chondocytes or any kind of mesenchyme originated cells which potentially can be converted to cartilage cells, generally by the influence of chondrogenic inducing factors, in combination with fibrinogen, antiprotease and thrombin. The cells ought to be of the species to which the composition is transplanted. It is advantageous to incorporate in the gel extracellular matrix (ECM) of chondrocytes or other hormones and/or growth factors such as SM (Somatomedin=IGF-I), FGF (fibroblast growth factor), CGF (cartilage growth factor), BDGF (bone derived growth factor) or a combination of any of these.
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Inventors:
SAMIYUERU ITEI
ZUBUI NEBUO
ZUBUI NEBUO
Application Number:
JP5519884A
Publication Date:
October 31, 1984
Filing Date:
March 21, 1984
Export Citation:
Assignee:
UNIV RAMOT
International Classes:
A61F2/30; A61B17/56; A61L24/10; A61L27/00; A61L27/38; C12N5/00; C12N5/077; A61F2/28; A61K35/12; (IPC1-7): A61B17/18; A61F1/00
Domestic Patent References:
| JPS5836545A | 1983-03-03 |
Attorney, Agent or Firm:
Mitsuo Adachi