Title:
4-AMINOETHOXY-5-ISOPROPYL-2-METHYL-PHENOL DERIVATIVE, MANUFACTURE AND MEDICINE
Document Type and Number:
Japanese Patent JPS5810543
Kind Code:
A
Abstract:
N-R2-N-CHR3-2-(2-isopropyl -4-OR1-5-methylphenoxy) ethylamines of formula (I) are new (where R1 is H, Me or COMe; R2 is H or Me; R3 is phenoxymethyl, 2,6-dimethoxyphenoxymethyl, 1,4-benzodioxan-2-yl or CH2CH2Ar, where Ar is phenyl opt. substd. by one or more substituents such as halogen, OH and OMe). (I) are alpha-1 blockers with long-lasting activity and low toxicity, and they also inhibit blood platelet aggregation. They can be used to treat arterial hypertension, peripheral vascular disease, asthma, glaucoma, thrombosis, etc. Effective doses are 1-100 mg/day (p.o.) and 0.1-10 mg (i.v.).
Inventors:
COURTIOL CHRISTIAN
CREUZET MARIE HELENE
FENIOU CLAUDE
PRAT GISELE
PONTAGNIE HENRI
CREUZET MARIE HELENE
FENIOU CLAUDE
PRAT GISELE
PONTAGNIE HENRI
Application Number:
JP5649082A
Publication Date:
January 21, 1983
Filing Date:
April 05, 1982
Export Citation:
Assignee:
CORTIAL
International Classes:
A61K31/05; A61K31/335; A61K31/357; A61P7/02; A61P25/02; C07C67/00; C07C213/00; C07C217/20; C07D319/20; (IPC1-7): A61K31/05; A61K31/135; A61K31/335; C07C93/06; C07D319/20
Attorney, Agent or Firm:
Yoshio Kawaguchi