To obtain a TNF-α production inhibitor useful as a treating agent for various diseases caused by excess production of the TNF-α by including at least one kind of specific three kinds of quinolonecarboxylic acids as an active ingredient.
This TNF-α production inhibitor includes at least one kind of quinolonecarboxylic acid of formulas I, II and III {X is H or a halogen; Y is X, a 1-4C alkyl, etc.; Z is a (protected) COOH, etc.; Q is N, a group of formula IV [R2 is H, a 1-4C alkyl (substituted by a halogen), etc.]; W is O or S; T is a 1-4C alkylene (substituted by a 1-4C alkyl), etc.; R1 is H, a 1-4C alkyl (substituted by OH, etc.), etc.; R is a group of formula V [R3 is a 6-10C arly (substituted by nitro, etc.), etc.; R4 and R5 are each H or a 1-4C alkyl; (n) is 1 or 2], etc.}. The compound of formulas I, II or III is produced by a method written in a laid open patent application of EP572,259 (Japan laid open patent application 6-116241) and/or a patent of WO/02512, or a method corresponding to these methods.
KURAKATA SHINICHI
NISHIGAKI TAKASHI
KIMURA TOMIO
KATSUBE TETSUTSUGU
UBE INDUSTRIES
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