TOLEROGENIC SYNTHETIC NANOCARRIER FOR ANTIGEN SPECIFIC DELETION OF T EFFECTOR CELLS

Title:

TOLEROGENIC SYNTHETIC NANOCARRIER FOR ANTIGEN SPECIFIC DELETION OF T EFFECTOR CELLS

Document Type and Number:

Japanese Patent JP2018008929

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a novel immunosuppressant therapy to produce immunosuppression related to undesirable immune responses.SOLUTION: According to the present invention, there is provided a method that comprises the step of administering to a subject a composition according to a protocol already shown to reduce the number or activity of antigen-specific T effector cells in one or more subjects. Here, the composition comprises: (i) a first population of synthetic nanocarriers coupled to an immunosuppressive drug; and (ii) a second population of synthetic nanocarriers coupled to MHC class I restricted and/or MHC class II restricted epitopes of the antigen.SELECTED DRAWING: Figure 5

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Inventors:

CHRISTOPHER FRASER
TAKASHI K KISHIMOTO
ROBERTO A MALDONADO

Application Number:

JP2017112098A

Publication Date:

January 18, 2018

Filing Date:

June 06, 2017

Export Citation:

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Assignee:

SELECTA BIOSCIENCES INC

International Classes:

A61K45/06; A61K39/00; A61K47/64; A61P37/06

Domestic Patent References:

JP2010505883A	2010-02-25
JP2009527566A	2009-07-30
JP2011500569A	2011-01-06

Other References:

BEEVERS CS, ET AL.: "Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells", INTERNATIONAL JOURNAL OF CANCER, vol. 119, no. 4, JPN6017003481, 2006, pages 757 - 764, ISSN: 0004096125
山口智之，坂口志文: "Around Hematologioal Malignancies 制御性T細胞", TRENDS IN HEMATOLOGICAL MALIGNANCIES, vol. 第２巻，第２号, JPN6016006011, May 2010 (2010-05-01), pages 96 - 98, ISSN: 0004096126

Attorney, Agent or Firm:

Kiyoji Kuzuwa

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