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Title:
TRANSCRIPTION FACTOR MODULATING COMPOUND AND METHOD OF USING THE SAME
Document Type and Number:
Japanese Patent JP2010235612
Kind Code:
A
Abstract:

To provide a substituted benzimidazole compound which is useful as an anti-infective agent lowering tolerability, toxicity or growth of microorganism.

This is provided a method of lowering resistance to antibiotics of microbial cells, including a step of bringing the cell into contact with a transcription factor modulating compound of formula (Va) (wherein R1 is OH, OCOCO2H or a substituted or unsubstituted linear or branched 1-5C alkyloxy group; R2 is H, CO2 or a substituted or unsubstituted aryl group; and R4, R5, R6 and R7 are independently selected from the group consisting of H, NO2 and halogen) to lower the resistance to antibiotics of the cells.


Inventors:
LEVY STUART B
ALEKSHUN MICHAEL N
PODLOGAR BRENT L
OHEMENG KWASI
VERMA ATUL K
WARCHOL TADEUSZ
BHATIA BEENA
BOWSER TODD
GRIER MARK
Application Number:
JP2010109145A
Publication Date:
October 21, 2010
Filing Date:
May 11, 2010
Export Citation:
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Assignee:
PARATEK PHARM INNC
International Classes:
A61K31/4184; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/495; A61K31/50; A61K31/535; A61K31/55; A61P31/00; A61P31/04; A61P43/00; C07D235/06; C07D235/08; C07D235/12; C07D235/14; C07D235/18; C07D235/22; C07D267/16; C07D401/04; C07D403/04; C07D405/04; C07D409/04; C07D413/04; C07D487/04; C07D491/04; C07D498/04; G02C13/00; C07D235/10
Domestic Patent References:
JP2002523459A2002-07-30
Foreign References:
NL6515833A1966-06-08
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi