Title:
TRANSLATABLE MOLECULES AND SYNTHESIS THEREOF
Document Type and Number:
Japanese Patent JP2023052106
Kind Code:
A
Abstract:
To provide molecules, structures and compositions having translational activity to provide active polypeptides and proteins both in vivo and in vitro.SOLUTION: Provided is a RNA that is expressible for providing a target polypeptide or protein, where the occurrence of uridines in the RNA coding sequence region is reduced by at least 20% as compared to a wild type mRNA that is expressible to provide the target polypeptide or protein, and the RNA contains one or more 5-methoxyuridines.SELECTED DRAWING: Figure 1
Inventors:
Patralani Rinfong
Kiyoshi Tachikawa
Padmanab Chibkra
Daiki Mazda
Alisa Kale
Kiyoshi Tachikawa
Padmanab Chibkra
Daiki Mazda
Alisa Kale
Application Number:
JP2022209557A
Publication Date:
April 11, 2023
Filing Date:
December 27, 2022
Export Citation:
Assignee:
Arcturus Therapeutics,Inc.
International Classes:
C12N15/12; A61K9/127; A61K9/51; A61K31/7088; A61K48/00; A61P35/00; A61P43/00; C12N15/85; C12N15/88
Attorney, Agent or Firm:
Yamato Kento
Norifumi Tomita
Fumio Inai
Manami Sasakura
Norifumi Tomita
Fumio Inai
Manami Sasakura