Title:
膜貫通ｐＨ勾配ポリマーソーム並びにアンモニア及びそのメチル化類似体の除去におけるそのポリマーソームの使用
Document Type and Number:
Japanese Patent JP7178090
Kind Code:
B2
Abstract:
The present invention provides polymersomes comprising non-biodegradable amphiphilic block-copolymers and their enteral (e.g., oral) or topical use in the treatment of an ammonia or ammonia methylated analog-associated disease or disorder or symptom thereof (e.g., hyperammonemia or trimethylaminuria). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid. It also provides a method of making the polymersome comprising mixing the copolymer-containing organic solvent phase with an aqueous phase containing the acid.
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Inventors:
Leroux, Jean-Christophe
Matori, Simon
Schmidt, Aaron Christophe
Matori, Simon
Schmidt, Aaron Christophe
Application Number:
JP2018567213A
Publication Date:
November 25, 2022
Filing Date:
August 15, 2017
Export Citation:
Assignee:
ETH Zurich
International Classes:
A61K31/765; A61K31/191; A61K47/12; A61K47/34; A61P3/00
Domestic Patent References:
| JP2015524452A | ||||
| JP2007208255A | ||||
| JP2011504937A | ||||
| JP2009510109A |
Other References:
R. C. Hayward et al.,Langmuir,2006年,22,4457-4461
Y. Men et al.,Polymer Chemistry,2016年,7,3977-3982
Z. Song et al.,ACS Appl. Mater. Interfaces,2016年,8,17033-17037
Y. Men et al.,Polymer Chemistry,2016年,7,3977-3982
Z. Song et al.,ACS Appl. Mater. Interfaces,2016年,8,17033-17037
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Kamoto Takahashi
Nao Oda
Akiyo Iwahori
Kamoto Takahashi