TRANSMUCOSAL DRUG DELIVERY SYSTEM

Japanese Patent JP2011074086

A

To provide a pharmaceutical composition containing an ionizable pharmaceutical agent and one or more kinds of complementary lipophilic chemical species.

There are disclosed preparations and formulations of high thermodynamic activity lipophilic associations (LA), in which there is pairing between an ionizable pharmaceutical agent and a lipophilic species having ionic characteristics opposite to that of the pharmaceutical agent. Such lipophilic associations manifest high thermodynamic activity, as evidenced by their being predominantly in a liquid phase at room temperature or solvated in a lower-than-water dielectric solvent. The pharmaceutical agent being solubilized means, further, that dissolution is not rate limiting to transmucosal absorption. This LA or LA-solvate is formulated into a low dielectric dosage form, from whence, upon the dosage form's hydration, the pharmaceutical agent is driven through the mucosal tissue and into systemic circulation. The invention therefore provides an enhanced transmucosal drug delivery system for ionizable pharmaceutical agents at or near physiological pH.

MCCARTY JOHN A

JP2011004397A

April 14, 2011

January 12, 2011

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PHARMACEUTICAL PRODUCTIONS INC

A61K47/44; A61K9/00; A61K9/02; A61K9/12; A61K9/14; A61K9/20; A61K9/48; A61K31/167; A61K31/4535; A61K31/465; A61K31/48; A61K45/00; A61K47/04; A61K47/10; A61K47/12; A61K47/14; A61K47/26; A61K47/34; A61K47/36; A61K47/38

JP2001521882A	2001-11-13
JP2001508027A	2001-06-19
JP2001517624A	2001-10-09
JPS62116507A	1987-05-28
JP2000512295A	2000-09-19
JPH08277216A	1996-10-22

JPN6010038826; Ｃｈｅｍｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ Ｖｏｌ．３９　，　Ｎｏ．１０, 1991, ｐｐ．２６５７-２６６１
JPN6010038827; Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｓｃｉｅｎｃｅｓ Ｖｏｌ．７９　，Ｎｏ．１２, 1990, ｐｐ．１０６５-１０７１

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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