Title:
GLP-1ペプチドまたはその類似体をコードし、分泌する、封入された細胞を用いた、急性心筋梗塞(AMI)の処置
Document Type and Number:
Japanese Patent JP2012502072
Kind Code:
A
Abstract:
The present application refers to the use of cells, e.g. mesenchymal stem cells or mesenchymal stromal cells, or any further suitable cell, encoding and secreting GLP-1, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof, for the treatment of acute myocardial infarction (AMI or MI), wherein the cells, encoding and secreting GLP-1, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof, are encapsulated in a (spherical) microcapsule to prevent a response of the immune system of the patient to be treated. The present application also refers to the use of these (spherical) microcapsule(s) or of a pharmaceutical composition containing these cells or (spherical) microcapsule(s) for the treatment of acute myocardial infarction (AMI or MI).
Inventors:
Vallap, Christine
Louise, Andrew, Leonard
Stratford, Peter, William
Eric Tenness
Louise, Andrew, Leonard
Stratford, Peter, William
Eric Tenness
Application Number:
JP2011526412A
Publication Date:
January 26, 2012
Filing Date:
September 11, 2009
Export Citation:
Assignee:
Bio Compatibles U.K. Limited
International Classes:
A61K35/12; A61K9/50; A61K38/00; A61P9/10; C07K19/00; C07K14/605; C12N5/077; C12N5/0775
Domestic Patent References:
| JP2001520640A | 2001-10-30 | |||
| JP2004535442A | 2004-11-25 |
Foreign References:
| WO2007128443A2 | 2007-11-15 | |||
| WO1999053064A2 | 1999-10-21 | |||
| WO2007039140A1 | 2007-04-12 |
Other References:
JPN6013058964; Ｃｉｒｃｕｌａｔｉｏｎ Ｖｏｌ．１０９， Ｎｏ．３, 2004, ｐ．９６２-９６５
JPN6013058966; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｏｌｌｅｇｅ ｏｆ Ｃａｒｄｉｏｌｏｇｙ Ｖｏｌ．５１， Ｎｏ．１０, 20080311, ｐ．Ａ３７８， １０３６-３１１
JPN6013058968; Ａｍｅｒｉｃａｎ Ｊｏｕｒｎａｌ ｏｆ Ｐｈｙｓｉｏｌｏｇｙ Ｖｏｌ．２８９， Ｎｏ．６， Ｐａｒｔ ２, 2005, ｐ．Ｈ２４０１-Ｈ２４０８
JPN6013058966; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｏｌｌｅｇｅ ｏｆ Ｃａｒｄｉｏｌｏｇｙ Ｖｏｌ．５１， Ｎｏ．１０, 20080311, ｐ．Ａ３７８， １０３６-３１１
JPN6013058968; Ａｍｅｒｉｃａｎ Ｊｏｕｒｎａｌ ｏｆ Ｐｈｙｓｉｏｌｏｇｙ Ｖｏｌ．２８９， Ｎｏ．６， Ｐａｒｔ ２, 2005, ｐ．Ｈ２４０１-Ｈ２４０８
Attorney, Agent or Firm:
Kenzo Hara International Patent Office