Title:
BLYSレセプターを標的化するためのBLYS融合タンパク質およびB細胞増殖性疾患の処置方法
Document Type and Number:
Japanese Patent JP2008528633
Kind Code:
A
Abstract:
The present invention regards targeted BLyS polypeptides capable of binding to BLyS receptors and that deliver a cytotoxic agent, such as a cytotoxic peptide, for example. In particular aspects, the cytotoxic agent comprises at least part of rGelonin. These compositions are useful for treating, preventing, and/or monitoring therapy for a B-cell proliferative disorder.
Inventors:
Rosen Bloom, Michael G.
Chan, Lawrence
Liu, Mie
Chan, Lawrence
Liu, Mie
Application Number:
JP2007553376A
Publication Date:
July 31, 2008
Filing Date:
February 01, 2006
Export Citation:
Assignee:
Research Development Foundation
International Classes:
C07K14/52; A61K38/00; A61K39/44; A61K47/42; A61K47/48; A61P17/02; A61P19/02; A61P35/00; A61P35/02; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita