Title:
CD30またはCD30Lのアンタゴニストを使用する自己免疫および慢性炎症性状態の処置法
Document Type and Number:
Japanese Patent JP4938957
Kind Code:
B2
Abstract:
The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of treating conditions resistant to treatment with TNFα inhibitors by administering agents that inhibit signal transduction by CD30 or IL-1. Included also are treatments involving concurrently administering agents that block the CD30/CD30L interaction and agents that antagonize the IL-4/IL-4R interaction. Additionally provided is an animal model for screening candidate agents for their efficacy in treating conditions that are resistant to treatment with TNFα inhibitors.
Inventors:
Möller, Kendall M
Baron, Dauphin S
Pachecheon, Jax Jay
Kennedy, Mary Kay
Plouennec, John Dee
Baron, Dauphin S
Pachecheon, Jax Jay
Kennedy, Mary Kay
Plouennec, John Dee
Application Number:
JP2002517101A
Publication Date:
May 23, 2012
Filing Date:
August 06, 2001
Export Citation:
Assignee:
IMMUNEX CORPORATION
International Classes:
A01K67/027; A61K39/395; A61K38/00; A61K45/00; A61K45/06; A61P17/02; A61P19/02; A61P25/00; A61P37/00; A61P37/06; C07K16/28; C12N15/09; G01N33/15; G01N33/48; G01N33/50
Foreign References:
| WO1999040187A1 | 1999-08-12 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya