To provide a pharmaceutical composition for preventing and treating acute and chronic GI (gastrointestine) disorders including nausea, vomiting, lactose intolerance, obstructive symptoms, diarrhea, mucositis, bleeding, weight loss and malnutrition.

The pharmaceutical composition for treating and/or preventing acute and chronic gastrointestinal disorder including nausea, vomiting, lactose intolerance, obstructive symptoms, diarrhea, mucositis, bleeding, weight loss and malnutrition is characterized by comprising a histon deacetylase (HDAC) inhibitor or a pharmaceutically permissible salt thereof, and a pharmaceutically permissible carrier thereof.