性ステロイド前駆体とＳＥＲＭとの併用による男性アンドロゲン欠乏症状又は疾患の治療

Japanese Patent JP7080117

B2

Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (DHEA) and a selective estrogen receptor modulator (SERM) (particularly acolbifene), an antiestrogen or a prodrug of the two. The symptoms or diseases are loss of libido, erectile dysfunction, tiredness, loss of energy, depression, bone loss, muscle loss, muscle weakness, fat accumulation, memory loss, cognition loss, Alzheimer's disease, dementia, loss of body hair, fertility problems, insomnia, gynecomastia, anemia, hot flushes, sweats, decreased sense of well-being, obesity, osteoporosis, hypercholesterolemia, hyperlipidemia, atherosclerosis, hypertension, insulin resistance, cardiovascular disease and type 2 diabetes. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.

Fernando Loveli
Sylvain Gautier

JP2018128308A

June 03, 2022

July 05, 2018

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ENDORECHERCHE, INC.

A61K31/192; A61K9/02; A61K9/06; A61K9/107; A61K9/20; A61K9/48; A61K31/352; A61K31/568; A61K31/5685; A61P3/02; A61P3/04; A61P3/06; A61P3/10; A61P5/26; A61P7/06; A61P9/00; A61P9/10; A61P9/12; A61P15/00; A61P15/08; A61P15/10; A61P17/14; A61P19/10; A61P21/00; A61P25/22; A61P25/24; A61P25/28

JP2003503446A
JP2008511615A

日本内科学会雑誌,2005年,Vol.94,No.10,p2195-2199
Journal of Clinical Endocrinology and Metabolism,2013年,Vol.98,No.9,p3615-3626

Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe

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