Title:
TGF-ベータ阻害剤による悪性神経膠腫の治療
Document Type and Number:
Japanese Patent JP2007517046
Kind Code:
A
Abstract:
The invention concerns methods of treating malignant gliomas, by administering inhibitors of TGF-beta the TGF-beta signaling pathway, including molecules preferably binding to the type I TGF-beta receptor (TGFbeta-R1). Preferably, the inhibitors are non-peptide small molecules, including quinazoline derivatives. The invention also concerns methods for reversing the TGF-beta-mediated effect on glioma cells to make them less refractile to signaling and other immune cells, comprising contacting a glioma cell or tissue in vivo or in vitro, with an inhibitor of TGF-beta.
Inventors:
Weller, Michael
Application Number:
JP2006547432A
Publication Date:
June 28, 2007
Filing Date:
December 22, 2004
Export Citation:
Assignee:
SIOS Incorporated
International Classes:
A61K31/4439; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/53; A61K31/5377; A61K31/55; A61K45/00; A61P35/00; A61P43/00; C07D239/47; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D409/14; C07D413/14; C07D487/04
Attorney, Agent or Firm:
Heikichi Odashima