Title:
神経栄養因子介在疾患の治療
Document Type and Number:
Japanese Patent JP2012515754
Kind Code:
A
Abstract:
An agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins and ester, ether, ketone and glycosylated forms thereof is used to induce self-regulated homeostasis of neurotrophic factors (NFs), for example BDNF and/or GDNF, NFs with limited and manageable side effects in a subject, by modulating NFs in a non-toxic manner under homeostatic control. An effective amount of at least one such agent is administered to the subject, particularly in the treatment or prevention of a range of NF-mediated disorders, particularly neurological, psychiatric, inflammatory, allergic, immune and neoplastic disorders, and in the restoration or normalisation of neuronal and other function in or in relation to any damaged or abnormal tissue, including when assisting tissue (for example, skin, bone, eye and muscle) healing and general skin, bone, eye and muscle health.
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Inventors:
Wreath, daryl
Orsi, Antonia
Hauston, patrick
Shea, Zonchin
Hou, Yaal
Orsi, Antonia
Hauston, patrick
Shea, Zonchin
Hou, Yaal
Application Number:
JP2011546964A
Publication Date:
July 12, 2012
Filing Date:
January 22, 2010
Export Citation:
Assignee:
PHYTOPHARM PLC
International Classes:
A61K31/58; A61K9/08; A61K9/10; A61K31/7048; A61K47/12; A61K47/14; A61P1/04; A61P1/08; A61P3/00; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P15/10; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P21/02; A61P21/04; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/02; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07J21/00; C07J71/00
Domestic Patent References:
| JP2005528370A | 2005-09-22 | |||
| JP2006502999A | 2006-01-26 | |||
| JP2007521815A | 2007-08-09 | |||
| JP2007517834A | 2007-07-05 |
Foreign References:
| WO2008077236A1 | 2008-07-03 |
Attorney, Agent or Firm:
Patent business corporation Kita Aoyama International