Title:
TREATMENT OF PERIPHERAL VASCULAR DISEASE USING POSTPARTUM-DERIVED CELLS
Document Type and Number:
Japanese Patent JP2014097995
Kind Code:
A
Abstract:
To provide cell based regenerative therapy for peripheral vascular disease patients, especially those with peripheral ischemia.
Compositions, kits etc. are provided using cells derived from postpartum tissue such as the umbilical cord and the placenta. The compositions etc. are used to stimulate and support angiogenesis, to improve a blood flow, to regenerate, repair and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients.
Inventors:
ANTHONY J KIHM
Application Number:
JP2013272225A
Publication Date:
May 29, 2014
Filing Date:
December 27, 2013
Export Citation:
Assignee:
ETHICON INC
International Classes:
A61K35/12; A61K35/48; A61K35/50; A61K45/00; A61L27/00; A61P9/00; A61P21/00; C12N5/071; C12N5/073
Domestic Patent References:
| JP5599568B2 | 2014-10-01 |
Foreign References:
| US20050054098A1 | 2005-03-10 |
Other References:
JPN6013043233; 移植， ２００４， ３９（５）， ｐ．５２２-５２７
JPN6013043236; 循環制御， ２００２， ２３（４）， ｐ．３９５-４０３
JPN6012043194; ＮＩＳＨＩＳＨＩＴＡ，Ｔ． ｅｔ ａｌ: 'Ａ ｐｏｔｅｎｔｉａｌ ｐｒｏ-ａｎｇｉｏｇｅｎｉｃ ｃｅｌｌ ｔｈｅｒａｐｙ ｗｉｔｈ ｈｕｍａｎ ｐｌａｃｅｎｔａ-ｄｅｒｉｖｅｄ ｍｅｓｅｎｃｈｙｍａｌ ｃｅｌｌｓ' Ｂｉｏｃｈｅｍ Ｂｉｏｐｈｙｓ Ｒｅｓ Ｃｏｍｍｕｎ Ｖｏｌ．３２５， Ｎｏ．１, 2004, ｐ．２４-３１
JPN6012043195; ＭＵＲＯＨＡＲＡ，Ｔ．: 'Ｔｈｅｒａｐｅｕｔｉｃ ｖａｓｃｕｌｏｇｅｎｅｓｉｓ ｕｓｉｎｇ ｈｕｍａｎ ｃｏｒｄ ｂｌｏｏｄ-ｄｅｒｉｖｅｄ ｅｎｄｏｔｈｅｌｉａｌ ｐｒｏｇｅｎｉｔｏｒｓ' Ｔｒｅｎｄｓ Ｃａｒｄｉｏｖａｓｃ Ｍｅｄ Ｖｏｌ．１１， Ｎｏ．８, 2001, ｐ．３０３-７
JPN7012003417; ＣＨＯ，Ｈ．Ｊ． ｅｔ ａｌ: 'Ｒｅｇｕｌａｔｉｏｎ ｏｆ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ ａｎｄ ｅｎｄｏｔｈｅｌｉａｌ ｐｒｏｇｅｎｉｔｏｒ ｃｅｌｌ ｓｕｒｖｉｖａｌ ａｎｄ ｖａｓｃｕｌｏｇｅｎｅｓｉｓ ｂｙ ｉｎｔｅｇｒ' Ａｒｔｅｒｉｏｓｃｌｅｒ Ｔｈｒｏｍｂ Ｖａｓｃ Ｂｉｏｌ Ｖｏｌ．２５， Ｎｏ．６, 2005, ｐ．１１５４-６０
JPN7012003418; ＩＫＥＤＡ，Ｙ． ｅｔ ａｌ: 'Ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ａｎｇｉｏｇｅｎｉｃ ｃｅｌｌ ａｎｄ ｇｅｎｅ ｔｈｅｒａｐｙ ｂｙ ｔｒａｎｓｐｌａｎｔａｔｉｏｎ ｏｆ ｕｍｂｉｌｉｃａｌ ｃｏｒｄ ｂｌｏｏｄ ｗｉｔｈ ｖａｓｃ' Ｈｙｐｅｒｔｅｎｓ Ｒｅｓ Ｖｏｌ．２７， Ｎｏ．２, 2004, ｐ．１１９-２８
JPN6013043236; 循環制御， ２００２， ２３（４）， ｐ．３９５-４０３
JPN6012043194; ＮＩＳＨＩＳＨＩＴＡ，Ｔ． ｅｔ ａｌ: 'Ａ ｐｏｔｅｎｔｉａｌ ｐｒｏ-ａｎｇｉｏｇｅｎｉｃ ｃｅｌｌ ｔｈｅｒａｐｙ ｗｉｔｈ ｈｕｍａｎ ｐｌａｃｅｎｔａ-ｄｅｒｉｖｅｄ ｍｅｓｅｎｃｈｙｍａｌ ｃｅｌｌｓ' Ｂｉｏｃｈｅｍ Ｂｉｏｐｈｙｓ Ｒｅｓ Ｃｏｍｍｕｎ Ｖｏｌ．３２５， Ｎｏ．１, 2004, ｐ．２４-３１
JPN6012043195; ＭＵＲＯＨＡＲＡ，Ｔ．: 'Ｔｈｅｒａｐｅｕｔｉｃ ｖａｓｃｕｌｏｇｅｎｅｓｉｓ ｕｓｉｎｇ ｈｕｍａｎ ｃｏｒｄ ｂｌｏｏｄ-ｄｅｒｉｖｅｄ ｅｎｄｏｔｈｅｌｉａｌ ｐｒｏｇｅｎｉｔｏｒｓ' Ｔｒｅｎｄｓ Ｃａｒｄｉｏｖａｓｃ Ｍｅｄ Ｖｏｌ．１１， Ｎｏ．８, 2001, ｐ．３０３-７
JPN7012003417; ＣＨＯ，Ｈ．Ｊ． ｅｔ ａｌ: 'Ｒｅｇｕｌａｔｉｏｎ ｏｆ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ ａｎｄ ｅｎｄｏｔｈｅｌｉａｌ ｐｒｏｇｅｎｉｔｏｒ ｃｅｌｌ ｓｕｒｖｉｖａｌ ａｎｄ ｖａｓｃｕｌｏｇｅｎｅｓｉｓ ｂｙ ｉｎｔｅｇｒ' Ａｒｔｅｒｉｏｓｃｌｅｒ Ｔｈｒｏｍｂ Ｖａｓｃ Ｂｉｏｌ Ｖｏｌ．２５， Ｎｏ．６, 2005, ｐ．１１５４-６０
JPN7012003418; ＩＫＥＤＡ，Ｙ． ｅｔ ａｌ: 'Ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ａｎｇｉｏｇｅｎｉｃ ｃｅｌｌ ａｎｄ ｇｅｎｅ ｔｈｅｒａｐｙ ｂｙ ｔｒａｎｓｐｌａｎｔａｔｉｏｎ ｏｆ ｕｍｂｉｌｉｃａｌ ｃｏｒｄ ｂｌｏｏｄ ｗｉｔｈ ｖａｓｃ' Ｈｙｐｅｒｔｅｎｓ Ｒｅｓ Ｖｏｌ．２７， Ｎｏ．２, 2004, ｐ．１１９-２８
Attorney, Agent or Firm:
Konobu Kato
Takafumi Oshima
Takafumi Oshima
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