TREATMENT OF TNFα-RELATED DISORDER

Title:

TREATMENT OF TNFα-RELATED DISORDER

Document Type and Number:

Japanese Patent JP2013056892

Kind Code:

A

Abstract:

To provide a pharmaceutical composition for treating psoriatic arthritis.

The pharmaceutical composition contains a therapeutically effective amount of an isolated human TNFα antibody or an antigen-binding portion thereof. The isolated human TNFα antibody or an antigen-binding portion thereof contains: a light chain variable region (LCVR) which includes CDR3 domain comprising an amino acid sequence of the specific sequence number, CDR2 domain comprising an amino acid sequence of the specific sequence number, and CDR1 domain comprising the amino acid sequence of the specific sequence number; and a heavy chain variable region (HCVR) which includes CDR3 domain comprising the amino acid sequence of the specific sequence number, CDR2 domain comprising an amino acid sequence of the specific sequence number, and CDR1 domain comprising an amino acid sequence of the specific sequence number.

Inventors:

BANERJEE SUBHASHIS
TAYLOR LORI K
SPIEGLER CLIVE E
TRACEY DANIEL EDWARD
CHARTASH ELIOT KEITH
HOFFMAN REBECCA S
BARCHUK WILLIAM T
YAN PHILIP
MURTAZA ANWAR
SALFELD JOCHEN G
FISCHKOFF STEVEN

Application Number:

JP2012225755A

Publication Date:

March 28, 2013

Filing Date:

October 11, 2012

Export Citation:

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Assignee:

ABBOTT BIOTECH LTD

International Classes:

A61K39/395; A61K45/00; A61P17/06; A61P19/02; A61P43/00; C07K16/24; C07K16/46; A61K; C07K

Domestic Patent References:

JP2000507810A	2000-06-27
JP2001525816A	2001-12-11
JP2001504479A	2001-04-03
JPH1072445A	1998-03-17

Other References:

JPN5005006553; ＫＥＭＰＥＮＩ　Ｊ．: ＡＮＮＵＡＬ　ＲＨＥＵＭＡＴＯＩＤ　ＤＩＳＥＡＳＥ．Ｖ５８，ＳＵＰＰＬ．Ｉ, 1999, Ｐ　Ｉ７０-Ｉ７２

Attorney, Agent or Firm:

Yoshio Kawaguchi
Katsuma Osaki

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