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Title:
TREHALOSE-CONTAINING MAMMALIAN CELL SUSPENSION FOR PREVENTION OF PULMONARY EMBOLISM FORMATION
Document Type and Number:
Japanese Patent JP2013233102
Kind Code:
A
Abstract:

To provide a mammalian cell suspension capable of preventing formation of pulmonary embolisms when mammalian cells such as mammalian stem cells are administered intraveniously, and a prophylactic agent against the formation of pulmonary embolisms when administering mammalian cells intraveniously.

Mammalian cells suspension for preventing the formation of pulmonary embolisms is prepared, when intraveniously administering mammalian cells, containing mammalian cells and trehalose or derivative thereof or salts of them as effective ingredient, by suspending mammalian cells such as mammalian stem cells in a physiological aqueous solution containing trehalose or derivative thereof or salts of them. As such a mammalian cell, islet cells, dendritic cells, natural killer cells, alpha-beta T cells, gamma-delta T cells and cytotoxic T cells, etc., are cited, and as mammalian stem cells, mammalian mesenchymal stem cells and mammalian pluripotent stem cells can be suitably exemplified.


Inventors:
WADA KEIKI
DOI MASAKO
KIKUCHI KENJI
KOBAYASHI EIJI
Application Number:
JP2012106866A
Publication Date:
November 21, 2013
Filing Date:
May 08, 2012
Export Citation:
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Assignee:
OTSUKA PHARMA FACTORY INC
International Classes:
C12N5/0775; A61K35/12; A61K35/28; A61K35/545; A61P9/00; C12N5/071
Domestic Patent References:
JPH114682A1999-01-12
JP2012500021A2012-01-05
JP2009296889A2009-12-24
JP2009521931A2009-06-11
JP2010239963A2010-10-28
JP2012500021A2012-01-05
JPH114682A1999-01-12
JP2009296889A2009-12-24
JP2009521931A2009-06-11
JP2010239963A2010-10-28
Other References:
JPN6013030748; 'Journal of Cellular Physiology' 14.12.2011, Vol.227, pp.879-884
JPN6013030748; 'Journal of Cellular Physiology' 14.12.2011, Vol.227, pp.879-884
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Large High Toshiko
High Kazuya Tsu
Makoto Horiuchi