Title:
トリアルキルカチオン性脂質およびその使用方法
Document Type and Number:
Japanese Patent JP6789918
Kind Code:
B2
Abstract:
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.
Inventors:
James haze
Mark wood
Alan Martin
Mark wood
Alan Martin
Application Number:
JP2017236756A
Publication Date:
November 25, 2020
Filing Date:
December 11, 2017
Export Citation:
Assignee:
Tekmira Pharmaceuticals Corporation
International Classes:
A61K47/28; A61K31/7088; A61K31/7105; A61K31/711; A61K47/18; A61K47/24; A61K48/00; A61P43/00; C07C217/08; C07C229/12; C07C271/20
Foreign References:
| WO2011143230A1 | ||||
| WO2011000106A1 | ||||
| WO2011153120A1 | ||||
| KR100996975B1 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe