Title:
ミクロソーム・トリグリセリド・トランスファータンパク質(MTP)及び/又はアポリポタンパク質B(APOB)分泌の阻害剤としてのトリアミド置換インドール、ベンゾフラン及びベンゾチオフェン
Document Type and Number:
Japanese Patent JP4139325
Kind Code:
B2
Abstract:
The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
Inventors:
Peter, vertinat
Blythe, Alan Elwood
Bronk, Brian Scott
Chen, Heng Miao
Huatan heap
lysine
Mason, Clive Philip
Blythe, Alan Elwood
Bronk, Brian Scott
Chen, Heng Miao
Huatan heap
lysine
Mason, Clive Philip
Application Number:
JP2003508914A
Publication Date:
August 27, 2008
Filing Date:
May 24, 2002
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07D209/42; A61K31/341; A61K31/343; A61K31/397; A61K31/404; A61K31/4045; A61K31/405; A61K31/4439; A61K31/4525; A61K31/4709; A61K31/501; A61K31/5377; A61P3/04; A61P3/06; A61P9/10; A61P43/00; C07D307/85; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/12; C07D413/12
Domestic Patent References:
| JP8119923A | ||||
| JP2001139555A | ||||
| JP2000505810A |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi