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Title:
TRIARYLALKENE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME DERIVATIVE, HAVING INHIBITORY ACTION ON TUMOR
Document Type and Number:
Japanese Patent JPH0539250
Kind Code:
A
Abstract:

PURPOSE: To obtain a triarylalkene derivative useful as a medicine or a pharmaceutically permissible salt thereof, showing more excellent antitumor effects on mammary tumor than tamoxifen.

CONSTITUTION: A compound shown by formula I [R1 and R2 are H, lower alkyl, lower cycloalkyl, R1 and R2 are heterocyclic group with the proviso that R1=R2=H is excluded; R3 is H, OH, OCOR5, OCH2OR6 or OPO(OH)2(OH)2; R4 and R5 are lower alkyl, lower cycloalkyl and, further, R5 is substituted aryl; R6 is lower alkyl or lower alkylcarbonyl; Ar is 3,4-methylenedioxyphenyl] or a pharmaceutically permissible salt thereof such as (E/Z)-1-[4-(2- cyclohexylaminoethoxy)phenyl-1-(4-hydroxyphenyl)-2-(3,4-methylenedioxyphenyl)-1- butene. The compound is produced from a compound shown by formula II (R7 is H or OH) and a compound shown by formula III through compounds shown by formula IV and formula V (X is halogen).


Inventors:
SHOJI HIROYUKI
ANDO SATOSHI
Application Number:
JP1991000219377
Publication Date:
February 19, 1993
Filing Date:
August 06, 1991
Export Citation:
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Assignee:
ASAHI CHEMICAL IND
International Classes:
A61K31/135; A61K31/138; A61K31/215; A61K31/22; A61K31/235; A61K31/36; A61K31/40; A61K31/66; A61K31/675; A61P35/00; C07C217/14; C07D295/08; C07F9/09; (IPC1-7): A61K31/135; A61K31/215; A61K31/22; A61K31/235; A61K31/36; A61K31/40; A61K31/66; A61K31/675; C07C217/14; C07D295/08; C07F9/09
Attorney, Agent or Firm:
清水 猛 (外1名)



 
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