To provide a novel compound that has high anti-microbial activity, is stable to dehydropeptidase I and shows high urinary content.
This is a novel compound represented by formula I [A is a heteroaryl monocyclic thio group that is represented by formula II (R1 and R2 are each a 1-6C alkyl, a 3-6C cycloalkyl or the like), or contains 1-3N, O or S atoms], its derivatives, their salts, typically (4R, 8S, 9R, 10 S)-4-(dibenzylamino-thiocarbonyl)thiomethyl-10-[(R)-1-hydroxyethyl]-11-oxo-1- azatricyclo[7.2.0.03.8]undeca-2-ene-2-carboxylic acid. This compound is prepared by sulfonylation of a compound of formula III before the sulfonylated product is allowed to react with a compound of the formula: Hap (Ap may be protected, when A includes hydroxyl or amino group), allowing the resultant intermediate to react with a compound of the formula: XCOCOOR14 (R14 is a protecting group of carboxyl; X is a halogen or the like) followed by ring closure reaction and final deprotection of the resultant intermediate.
SUGANO OSAMU
SHIMOJI YASUO
OYA SATORU
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