TRICYCLIC CONDENSED HETEROCYCLIC DERIVATIVE, ITS PRODUCTION AND USE

Japanese Patent JP3286056

B2

PURPOSE: To obtain a tricyclic condensed heterocyclic derivative, having excellent inhibiting activities against choline esterases and inhibiting actions on uptake of monoamines and useful as a therapeutic and preventing agent for senile dementia by reacting a specific compound with a compound having piperidinyl group.
CONSTITUTION: This compound is expressed by formula I [Ar is a tricyclic condensed benzene ring which has a heterocyclic ring condensed thereto and may have a substituent group; n is 2-10; R1 is H or a (substituted)hydrocarbon; Y is a (substituted)4-piperidinyl, 1-piperazinyl or 4-benzyl-1-piperidinyl]. This method for producing the compound is to specifically react 8-[3-[4-[(3- methylphenyl)methyl]-1-piperazinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H- pyrrolo[3,2,1-ij]quinolin-4--one, etc., with a compound expressed by the formula Ar-H, etc., and a compound expressed by formula II (Z1 is an eliminative group) or its salt.

Yoshikazu Goto
Yuji Ishihara
Keisuke Hirai

JP331994A

May 27, 2002

January 18, 1994

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Takeda GmbH

C07D319/08; A61K31/00; A61K31/40; A61K31/403; A61K31/427; A61K31/4355; A61K31/4427; A61K31/443; A61K31/4433; A61K31/445; A61K31/4465; A61K31/451; A61K31/454; A61K31/4545; A61K31/47; A61K31/473; A61K31/4745; A61K31/495; A61K31/496; A61K31/506; A61K31/535; A61K31/5377; A61K31/538; A61K31/54; A61K31/5415; A61K31/55; A61K31/551; A61P25/28; A61P43/00; C07D209/86; C07D209/92; C07D209/94; C07D211/32; C07D211/46; C07D221/14; C07D221/16; C07D223/18; C07D223/20; C07D223/22; C07D265/38; C07D267/20; C07D279/20; C07D279/22; C07D307/91; C07D311/82; C07D313/14; C07D327/08; C07D337/14; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D405/06; C07D405/12; C07D405/14; C07D409/06; C07D409/12; C07D411/06; C07D413/06; C07D417/06; C07D417/12; C07D471/06; C07D487/04; C07D487/06; C07D491/113; (IPC1-7): C07D401/06; A61K31/403; A61K31/427; A61K31/4355; A61K31/454; A61K31/4545; A61K31/473; A61K31/4745; A61K31/496; A61K31/506; A61K31/5377; A61K31/55; A61K31/551; A61P25/28; A61P43/00; C07D209/86; C07D209/92; C07D209/94; C07D211/32; C07D211/46; C07D221/14; C07D221/16; C07D223/18; C07D223/20; C07D223/22; C07D265/38; C07D267/20; C07D279/20; C07D279/22; C07D307/91; C07D311/82; C07D313/14; C07D319/08; C07D327/08; C07D337/14; C07D401/12; C07D401/14; C07D403/12; C07D405/06; C07D405/12; C07D405/14; C07D409/06; C07D409/12; C07D411/06; C07D413/06; C07D417/06; C07D417/12; C07D471/06; C07D487/04; C07D487/06; C07D491/113

Aoyama Ryo (5 people outside)

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