TRICYCLIC CONDENSED HETEROCYCLIC DERIVATIVE, METHOD FOR PRODUCING THE SAME AND APPLICATION OF THE SAME

Japanese Patent JP3819759

B2

PROBLEM TO BE SOLVED: To provide a compound having excellent choline esterase inhibitory activity and monoamine intake inhibitory activity, thus useful as a prophylactic/ therapeutic agent for senile dementia.
SOLUTION: This compound (a salt thereof) is shown by the formula [Ar is a tricyclic condensed benzene ring group formed by condensing at least one heterocyclic ring and optionally has substituent (s); n is an integer of 2-10; R1 is H or a (substituted) hydrocarbon group; and Y is a (substituted) 4- piperidinyl, (substituted) 1-piperazinyl or (substituted) 4-benxyl-1-piperidinyl]. The other objective method for producing the above compound (salt) and an agent comprising the above compound (salt) are also provided, respectively.

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Yoshikazu Goto
Yuji Ishihara
Keisuke Hirai

JP2001336391A

September 13, 2006

January 18, 1994

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Takeda GmbH

C07D209/86; C07D221/14; A61K31/343; A61K31/395; A61K31/454; A61K31/473; A61K31/4745; A61K31/496; A61K31/55; A61K31/553; A61P25/28; A61P43/00; C07D209/90; C07D209/92; C07D223/18; C07D223/20; C07D225/08; C07D267/20; C07D307/91; C07D401/06; C07D413/06; C07D471/16; (IPC1-7): C07D209/86; A61K31/343; A61K31/395; A61K31/454; A61K31/473; A61K31/4745; A61K31/496; A61K31/55; A61K31/553; A61P25/28; A61P43/00; C07D209/90; C07D209/92; C07D221/14; C07D223/18; C07D225/08; C07D267/20; C07D307/91; C07D401/06; C07D413/06; C07D471/16

EP0487071A1

Aoyama Aoi
Mitsuo Tanaka
Naoyuki Miyagawa

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