NEW MATERIAL:The compound of formula I [R1 is OH, group of formulaII(R4 is H or alkanoyl; R5 is H or alkyl), alkanoyloxy, etc.: R2 is hydroxymethyl, formyl, etc.; R1 and R2 may together form the group of formula III (R7 and R8 are R5); R3 is OH, oxo, hydroxyimino, sulfoxy, phosphonoxy, group of formula II, etc.] and its salt.
EXAMPLE: [Olean-12-ene-22,23(4β)-dioxo-3β-yl]-β-D-glucopyranoside uronic acid.
USE: It has excellent anticomplimentary activity and blood platelet coagulation suppressing activity, and is useful as a preventive and remedy for immune diseases or autoimmune diseases such as nephritis, rheumatoid, systemic lupus erythematous, etc., and thrombosis.
PREPARATION: The compound of formula I can be prepared e.g. by reacting the compound of formula IV with the compound of formula V (R4' is alkanoyl; R5' is alkyl), and reacting the product with the compound of formula (R6)2O or R6× (R6 is alkanoyl).
| JP2003519674 | [Title of Invention] Method for Producing Betulinic Acid |
| WO/2001/051451 | METHODS FOR MANUFACTURING BETULINIC ACID |
KAISE HIROTSUGU
IZAWA TAKETOSHI
| JPS6092300A | 1985-05-23 |