Title:
Trk prevention compound
Document Type and Number:
Japanese Patent JP5954486
Kind Code:
B2
Abstract:
The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I):wherein all symbols represent the same meanings as described in the specification,a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.
Inventors:
Atsushi Takeuchi
Itaya Satoshi
Hayamura Keiya
Ikura Seiyasu
Katsuhito Higashino
Tetsuya Kasuhiro
Takeshi Nagaura
Itaya Satoshi
Hayamura Keiya
Ikura Seiyasu
Katsuhito Higashino
Tetsuya Kasuhiro
Takeshi Nagaura
Application Number:
JP2015501443A
Publication Date:
July 20, 2016
Filing Date:
February 18, 2014
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
C07D401/14; A61K31/506; A61P1/02; A61P1/04; A61P13/02; A61P17/04; A61P19/02; A61P19/10; A61P25/02; A61P25/06; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2007535565A | 2007-12-06 | |||
| JP2007182433A | 2007-07-19 | |||
| JP2009534450A | 2009-09-24 | |||
| JP2005522448A | 2005-07-28 | |||
| JP2006519266A | 2006-08-24 |
Foreign References:
| CN101717373A | 2010-06-02 | |||
| US20120225057A1 | 2012-09-06 | |||
| WO2013161919A1 | 2013-10-31 |
Other References:
JPN6014020863; ＳＵＮ，Ｍｉｎ ｅｔ ａｌ: Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４５, 2010, ｐｐ．２２９９-２３０６
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office