Title:
TUMOR NECROSIS FACTOR SUPERFAMILY AND TNF-LIKE LIGAND MUTEIN AND METHOD OF PREPARING AND USING THE SAME
Document Type and Number:
Japanese Patent JP2021191273
Kind Code:
A
Abstract:
To provide methods of secondary crosslinking to increase the half-life of a tumor necrosis factor superfamily (TNFSF).SOLUTION: The present invention discloses homo-multimers, e.g., homo-trimers, of TNFSF or TNF-like ligand muteins in which each TNFSF ligand or TNF-like ligand mutein monomer contains at least one cysteine residue substitution or insertion that promotes the formation of a disulfide bond with a cysteine residue on a neighboring TNFSF or TNF-like ligand mutein monomer. The invention also discloses methods of producing such TNFSF and TNF-like ligand muteins, pharmaceutical compositions containing such muteins, as well as methods of using such muteins in cancer immunotherapy, in treating autoimmune and neurological diseases, and in reducing or eliminating the complications and risks of rejection in organ transplantation or tissue or organ repair or regeneration.SELECTED DRAWING: None
Inventors:
DENISE L FAUSTMAN
EVA VANAMEE
EVA VANAMEE
Application Number:
JP2021130265A
Publication Date:
December 16, 2021
Filing Date:
August 06, 2021
Export Citation:
Assignee:
MASSACHUSETTS GEN HOSPITAL
International Classes:
C12N15/12; A61K38/02; A61K38/16; A61K38/19; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P19/08; A61P21/02; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P27/02; A61P31/00; A61P31/06; A61P31/08; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/06; A61P37/08; C07K14/52; C07K14/525; C07K14/575; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/16; C12N15/28; C12N15/86; C12N15/861; C12N15/863; C12N15/864; C12N15/867; C12P21/02
Domestic Patent References:
| JP2017525370A | 2017-09-07 | |||
| JPS63119692A | 1988-05-24 |
Foreign References:
| US20030138401A1 | 2003-07-24 | |||
| US5487984A | 1996-01-30 |
Other References:
NIELSEN F. S. ET AL.: "Insertion of Foreign Tcell Epitopes in Human Tumor Necrosis Factor α with Minimal Effect on Protein", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 32, JPN6019033456, 6 August 2004 (2004-08-06), pages 33593 - 33600, ISSN: 0005029107
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Takashima Ejima
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Takashima Ejima
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