Title:
二つの部分からなる低分子量の癌および血管新生の抑制剤
Document Type and Number:
Japanese Patent JP4991527
Kind Code:
B2
Abstract:
The present invention provides analogs and derivatives of thalidomide which inhibit cancer and angiogenesis. The present invention further provides compounds which disrupt microtubule polymerization. The present further provides methods of treating cancers comprising mutant p53.
Inventors:
Brown, Milton, Elle.
Application Number:
JP2007515530A
Publication Date:
August 01, 2012
Filing Date:
June 01, 2005
Export Citation:
Assignee:
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
International Classes:
A61K31/517; A61K31/47; A61K45/00; A61P9/00; A61P17/00; A61P19/02; A61P21/00; A61P27/02; A61P27/06; A61P35/00; C07D217/24; C07D221/12; C07D221/16; C07D237/30; C07D239/91; C07D243/14; C07D245/04; C07D401/12; C07D405/04; C07D409/04; C07D471/04; C07D487/04; C07D491/04; C07D495/04
Foreign References:
| WO2004031118A1 |
Other References:
Biochemical Pharmacology,1996年,Vol.51,P.53-59
Arch. Pharm. Res.,2001年,Vol.24,No.4,P.276-280
Bioorganic and Medicinal Chemistry,2002年,Vol.10,P.2953-2961
The Journal of Organic Chemistry,1969年,Vol.34,No.4,P.887-892
Arch. Pharm. Res.,2001年,Vol.24,No.4,P.276-280
Bioorganic and Medicinal Chemistry,2002年,Vol.10,P.2953-2961
The Journal of Organic Chemistry,1969年,Vol.34,No.4,P.887-892
Attorney, Agent or Firm:
Yoshiyuki Osuga