Title:
１，１，１，３，３，３−ヘキサフルオロプロパン−２−オールと脂肪族炭化水素系溶媒を用いた二相系反応媒体
Document Type and Number:
Japanese Patent JP6839356
Kind Code:
B2
Abstract:
This two-phase reaction medium for an organic reaction includes: a first liquid phase which uses 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) as a solvent; and a second liquid phase comprising a solvent that is essentially incompatible with the HFIP and that has an aliphatic hydrocarbon, preferably a C5-30 aliphatic hydrocarbon (the aliphatic hydrocarbon being straight-chain, branched-chain or cyclic, and in which a portion of the C-C bonds thereof may form double or triple bonds), or a combination thereof as main components (meaning that the solvent includes these components in a ratio of 50% or greater). Through use of the two-phase reaction medium, it is possible to realize a novel reaction system whereby undesired secondary reactions can be suppressed while the reactivity-promoting effect of the HFIP solvent in an organic reaction is maintained. In particular, when the two-phase reaction medium is used, the yield of the object substance in a phenacene synthesis reaction by "intramolecular hydroarylation of an inert alkyne" is markedly enhanced relative to a case in which HFIP alone is used as the solvent.
Inventors:
Atsushi Ichikawa
Takeshi Fujita
Kazumitsu Takahashi
Takeshi Fujita
Kazumitsu Takahashi
Application Number:
JP2017039790A
Publication Date:
March 10, 2021
Filing Date:
March 02, 2017
Export Citation:
Assignee:
Central Glass Co., Ltd.
International Classes:
C07C5/31; C07C15/30; C07C17/358; C07C25/22
Domestic Patent References:
| JP2010530295A |
Other References:
QIAN, Jing, et al.,Journal of Chromatography A,2007年,1143,pp. 276-283,Table 4
LI, Qi, et al.,Chemical Communications,2015年,51,pp. 7219-7221,Figure S2(B)
FUJITA, Takeshi, et al.,European Journal of Organic Chemistry,2017年,2017,pp. 262-265
LI, Qi, et al.,Chemical Communications,2015年,51,pp. 7219-7221,Figure S2(B)
FUJITA, Takeshi, et al.,European Journal of Organic Chemistry,2017年,2017,pp. 262-265