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Title:
TYROSINASE-INHIBITOR
Document Type and Number:
Japanese Patent JPH04235112
Kind Code:
A
Abstract:

PURPOSE: To obtain a tyrosinase-inhibitor usable as a skin-beautifying agent for cosmetic and an agent for preventing blackening and browning of food, etc., by using 1,3,5-trihydroxybenzene derivative as an active component.

CONSTITUTION: The active component of the objective tyrosinase-inhibitor is the compound of formula I (R1 is H or glucose residue; R2 is H or group of formula II ; at least one of R1 groups is H but all of R1 and R2 groups are not H at the same time), e.g. phlorin of formula III, phloridzin of formula IV or phloretin of formula V. These compounds have remarkable tyrosinase- inhibiting activity comparable or superior to that of known agent such as kojic acid and arbutin. The amount of the compound is preferably about 0.5-1g per 100g of cosmetic in the case of using as a skin-beautifying cosmetic or 1-2g per 100l of solution in the case of using as a blackening preventing agent for food preferably in the form of an aqueous solution or an organic solvent solution.


Inventors:
MITANI YASUMASA
SAKAI SHUNSUKE
Application Number:
JP202091A
Publication Date:
August 24, 1992
Filing Date:
January 11, 1991
Export Citation:
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Assignee:
TEI EE SHII GIJIYUTSU KAGAKU K
International Classes:
A23B4/20; A23B4/14; A23B7/14; A23B7/153; A61K8/00; A61K8/33; A61K8/60; A61K31/12; A61K31/70; A61K31/7028; A61K31/7034; A61P17/00; A61P43/00; A61Q19/02; C07C49/825; C07H15/203; C12N9/99; (IPC1-7): A23B4/20; A23B7/14; A23B7/153; A61K7/00; A61K31/12; A61K31/70; C07C49/825; C07H15/203; C12N9/99
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)