Title:
チロシンキナーゼ阻害薬
Document Type and Number:
Japanese Patent JP4332112
Kind Code:
B2
Abstract:
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
Inventors:
Dansmore, Christopher The Ray
Vishyoa, Douglas Sea
Bergman, Jeffrey M
Linsley, Craig Davryu
Vishyoa, Douglas Sea
Bergman, Jeffrey M
Linsley, Craig Davryu
Application Number:
JP2004527799A
Publication Date:
September 16, 2009
Filing Date:
August 05, 2003
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D209/42; C07D487/10; A61K31/138; A61K31/337; A61K31/40; A61K31/404; A61K31/407; A61K31/438; A61K31/44; A61K31/4465; A61K31/4535; A61K31/454; A61K31/4545; A61K31/495; A61K31/496; A61K31/5377; A61K31/541; A61K31/547; A61K31/55; A61K31/551; A61K31/553; A61K39/395; A61K45/00; A61P1/04; A61P3/10; A61P27/02; A61P35/00; A61P37/02; A61P43/00; C07D209/02; C07D209/96; C07D211/02; C07D215/02; C07D267/02; C07D401/04; C07D401/12; C07D401/14; C07D403/02; C07D403/04; C07D403/12; C07D405/04; C07D405/12; C07D409/04; C07D413/02; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D417/14; C07D451/02; C07D491/04; C07D491/048; C07D491/08; C07D491/10; C07D491/107; C07D491/12; C07D498/04; C07D513/04; C07D513/08; C07D
Domestic Patent References:
| JP8507067A | ||||
| JP2002511852A |
Foreign References:
| WO2000046199A1 |
Other References:
Jacob Szmuszkovicz,Reaction of Indole Derivatives with Thionyl and Sulfuryl Chlorides,The Journal of Organic Chemistry,1964年,Vol.29, No.1,pp.178-184
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura