Title:
チロシンキナーゼの阻害剤
Document Type and Number:
Japanese Patent JP4895976
Kind Code:
B2
Abstract:
The invention relates to compounds of formula
wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukaemia, and a method for the treatment of such a disease.
Inventors:
Werner Breitenstein
Pascal Fure
Sandra Jacob
Paul William Manly
Pascal Fure
Sandra Jacob
Paul William Manly
Application Number:
JP2007283773A
Publication Date:
March 14, 2012
Filing Date:
October 31, 2007
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D401/04; A61K31/506; A61K31/5377; A61K31/55; A61P3/10; A61P9/10; A61P11/06; A61P13/12; A61P15/08; A61P17/06; A61P27/02; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/06; A61P43/00; C07D401/14; C07D405/14; C07D417/14
Domestic Patent References:
| JP6184116A | ||||
| JP8504215A | ||||
| JP4110140B2 |
Other References:
ZIMMERMANN J,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,1997年 1月21日,V7 N2,P187-192
ZIMMERMANN J,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,1996年 6月 4日,V6 N11,P1221-1226
PAUL R,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY.,1993年 9月17日,V36 N19,P2716-2725
Dorsey,Abstracts/Experimental Hematology,2000年 7月,Vol.28, No.7, Suppl.1,pp.49
Simone,Oncology:Introduction,Cecil Textbook of Medicine,1996年,20th Edition,Vol.1,pp.1004-1010
Taxler,Protein Tyrosine Kinase Inhibitors in cancer treatment,Exp.Opin.Ther.Patents,1997年,Vol.7, No.6,pp.571-588
ZIMMERMANN J,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,1996年 6月 4日,V6 N11,P1221-1226
PAUL R,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY.,1993年 9月17日,V36 N19,P2716-2725
Dorsey,Abstracts/Experimental Hematology,2000年 7月,Vol.28, No.7, Suppl.1,pp.49
Simone,Oncology:Introduction,Cecil Textbook of Medicine,1996年,20th Edition,Vol.1,pp.1004-1010
Taxler,Protein Tyrosine Kinase Inhibitors in cancer treatment,Exp.Opin.Ther.Patents,1997年,Vol.7, No.6,pp.571-588
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi