Title:
UBE2T peptide and vaccine containing it
Document Type and Number:
Japanese Patent JP6283861
Kind Code:
B2
Abstract:
Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the UBE2T that CTLs are provided. Isolated antigen-presenting cells with CTL inducibility and CTLs that target such peptides, as well as methods for inducing the antigen-presenting cell, or CTL are also provided. The present invention further provides pharmaceutical compositions containing such epitope peptides derived from UBE2T or polynucleotides encoding the polypeptides as active ingredients. Furthermore, the present invention provides methods for the treatment and/or prophylaxis of (i.e., preventing) cancers (tumors), and/or the prevention of a postoperative recurrence thereof, as well as methods for inducing CTLs, methods for inducing anti-tumor immunity, using the epitope peptides derived from UBE2T, polynucleotides encoding the peptides, or antigen-presenting cells presenting the peptides, or the pharmaceutical compositions of the present invention.
Inventors:
Takuya Tsunoda
Ryuji Osawa
Yoshimura Sachiko
Watanabe Asahisa
Ryuji Osawa
Yoshimura Sachiko
Watanabe Asahisa
Application Number:
JP2015530559A
Publication Date:
February 28, 2018
Filing Date:
September 09, 2013
Export Citation:
Assignee:
OncoTherapy Science Co., Ltd.
International Classes:
C12N9/10; A61K31/7088; A61K35/14; A61K35/15; A61K35/17; A61K38/08; A61K39/00; A61P35/00; C07K7/06; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/078; C12N5/0783; C12N5/10; C12N15/09; C12Q1/02; G01N33/15
Domestic Patent References:
| JP2010531133A | ||||
| JP2012513742A | ||||
| JP2012510794A |
Foreign References:
| WO2010032696A1 | ||||
| WO2012073459A1 | ||||
| WO2012053206A1 | ||||
| WO2012053200A1 |
Other References:
HAO, J. et al.,"Elevated expression of UBE2T in lung cancer tumors and cell lines.",TUMOUR BIOLOGY,2008年,Vol.29, No.3,P.195-203
UEKI, T. et al.,"Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.",CANCER RESEARCH,2009年11月15日,Vol.69, No.22,P.8752-8760
UEKI, T. et al.,"Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.",CANCER RESEARCH,2009年11月15日,Vol.69, No.22,P.8752-8760
Attorney, Agent or Firm:
Masao Haruna
Hatsushi Shimizu
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Hatsushi Shimizu
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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