PURPOSE: To provide the titled compound obtained by including ubidecarenone in γ-cyclodextrin, keeping the activity of ubidecarenone without lowering its bioavailability, resistant to the decomposition with light, and applicable easily as a drug preparation.
CONSTITUTION: The ubidecarenone which is a kind of coenzyme Q acting as an electron carrier in the oxidative phosphorylation and known to have various drug actions is included in γ-cyclodextrin by solution process, kneading process, etc., preferably by solution process. For example, ubidecarenone is mixed with γ-cyclodextrin and water, and the mixture is stirred at room temperature in a sealed state. It is expected to be usable as a raw material of an injection.
EFFECT: It can be left standing in air for a long period without causing red color development. The poor thermal stability and the difficulty in the preparation of a drug caused by the low melting point of γ-cyclodextrin can be solved in the present clathrate compound.
IIJIMA MASAO
ZERIA PHARM CO LTD
JPS5369820A | 1978-06-21 |