Title:
ULTRAFINE L-CARNITINE, METHOD FOR PREPARING THE SAME, COMPOSITION CONTAINING THE SAME, AND METHOD OF USING THE SAME
Document Type and Number:
Japanese Patent JP2009067809
Kind Code:
A
Abstract:
To provide L-carnitine having a configuration exhibiting a high bioavailability by oral administration, and its salt; to provide L-carnitine having a configuration easily preparable by combining another component (for example, an oil-based material) incapable of blending with L-carnitine of bulk, and its salt; and to provide L-carnitine having a configuration exhibiting a decreased hygroscopicity and its salt.
L-carnitine provided has a particle size such that it substantially passes through a 100 USBS mesh sieve. The L-carnitine exhibits an increased bioavailability and a decreased hygroscopicity and may be conveniently formulated with oil-based materials to give a drug product.
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Inventors:
HASSEN KEN
Application Number:
JP2008284482A
Publication Date:
April 02, 2009
Filing Date:
November 05, 2008
Export Citation:
Assignee:
SIGMA TAU IND FARMACEUTI
International Classes:
A61K31/205; A61K45/00; A23L1/305; A23L33/20; A61K9/14; A61K31/05; A61K31/122; A61K31/194; A61K31/202; A61K31/221; A61K31/44; A61K47/04; A61P3/06; A61P9/00
Domestic Patent References:
JPS60158152A | 1985-08-19 | |||
JPH06199751A | 1994-07-19 | |||
JPH08259445A | 1996-10-08 |
Foreign References:
WO1999027925A1 | 1999-06-10 | |||
WO1998041113A2 | 1998-09-24 | |||
WO1997046512A1 | 1997-12-11 | |||
WO1997046512A1 | 1997-12-11 | |||
WO1998038157A1 | 1998-09-03 |
Other References:
JPN6007001578; International Journal of Pharmaceutics Vol.125, 1995, p.91-97
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation