Title:
Unauthorized use resistance dosage forms containing an anionic polymer
Document Type and Number:
Japanese Patent JP5933553
Kind Code:
B2
Abstract:
A pharmaceutical dosage form and method of using same, the pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); a physiologically acceptable polymer (B) obtainable by polymerization of a monomer composition comprising an ethylenically unsaturated monomer bearing an anionic functional group, in protonated form or a physiologically acceptable salt thereof; a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the polymer (B) and the polyalkylene oxide (C).
Inventors:
Balnscheid Lutz
Schwerer Sebastian
Bartholomew Johannes
Schwerer Sebastian
Bartholomew Johannes
Application Number:
JP2013526360A
Publication Date:
June 15, 2016
Filing Date:
September 01, 2011
Export Citation:
Assignee:
Grunenthal Gesellschaft Mito Beschlenktel Haftung
International Classes:
A61K9/20; A61K47/32; A61K47/34
Domestic Patent References:
| JP2008504327A | ||||
| JP2007501201A | ||||
| JP2009531453A |
Foreign References:
| WO2010022193A1 | ||||
| WO2010083894A1 |
Other References:
European Journal of Pharmaceutics and Biopharmaceutics Volume 59, Issue 1, January 2005, Pages 85-97
Arch Pharm Res. 2008 Mar;31(3):399-405
OZEKI T,CONTROLLED RELEASE FROM SOLID DISPERSION COMPOSED OF POLY(ETHYLENE OXIDE)-CARBOPOL 以下備考,JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER,2000年 2月 3日,V63 N3,P287-295,INTERPOLYMER COMPLEX WITH VARIOUS CROSS-LINKING DEGREES OF CARBOPOL
HONG S I,DISSOLUTION KINETICS AND PHYSICAL CHARACTERIZATION OF THREE-LAYERED TABLET 以下備考,INTERNATIONAL JOURNAL OF PHARMACEUTICS,NL,ELSEVIER BV,2008年 5月22日,V356 N1-2,P121-129,WITH POLY(ETHYLENE OXIDE) CORE MATRIX CAPPED BY CARBOPOL
Arch Pharm Res. 2008 Mar;31(3):399-405
OZEKI T,CONTROLLED RELEASE FROM SOLID DISPERSION COMPOSED OF POLY(ETHYLENE OXIDE)-CARBOPOL 以下備考,JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER,2000年 2月 3日,V63 N3,P287-295,INTERPOLYMER COMPLEX WITH VARIOUS CROSS-LINKING DEGREES OF CARBOPOL
HONG S I,DISSOLUTION KINETICS AND PHYSICAL CHARACTERIZATION OF THREE-LAYERED TABLET 以下備考,INTERNATIONAL JOURNAL OF PHARMACEUTICS,NL,ELSEVIER BV,2008年 5月22日,V356 N1-2,P121-129,WITH POLY(ETHYLENE OXIDE) CORE MATRIX CAPPED BY CARBOPOL
Attorney, Agent or Firm:
Mitsufumi Esaki
Blacksmith
Katsunori Uenishi
Blacksmith
Katsunori Uenishi