To obtain a new urea derivative useful as an active ingredient of a medicine used for prevention and/or treatment of diseases such as hyperlipemia or arteriosclerosis.
This urea derivative is represented by formula I [R1 to R3 are each H, OH, an alkyl, an alkoxy, an aralkyloxy, etc.; R4 is H, an alkyl, a cycloalkyl, etc.; R5 to R7 are each H, an alkoxy, an alkyl, OH, etc.; Y is an alkyl, an aryl, etc.; (k) is 0-3; (1) is 2-4], its salt, hydrate or solvate, e.g. N-{4-(4-methyl-1-piperazinyl)phenyl}methyl-N'-[2-{3-(4-phenyl-1-piperazinyl) propoxy}-6-methylphenyl]urea. The compound represented by formula I is obtained by converting an aniline derivative represented by formula II into a reactional intermediate represented by formula III (Z is a halogen, an aryloxy, etc.), then reacting the resultant intermediate with an amine derivative represented by formula IV in which (k) is 1-3 or an aniline derivative represented by formula IV in which (k) is 0.
TARAO YOSHIHIRO
KOMATSU YOSHIYUKI
SUZUKI KAZUO
TAKAHASHI CHIZUKO
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