Title:
PPARモジュレーターとして用いるためのウレアリンカー誘導体
Document Type and Number:
Japanese Patent JP2005517008
Kind Code:
A
Abstract:
The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each independently selected from the group consisting of hydrogen, C1-C8 alkyl substituted C1-C8 alkyl, aryl-C0-4-alkyl, substituted aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, substituted heteroaryl-C0-4-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl, and substituted C3-C6 cycloalkylaryl-C0-2-alkyl; (b) X is an optionally substituted C1-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S; (c) Y is C, O, S, NH or a single bond; and (d) E is selected from the group consisting of hydrogen, C(R3)(R4)A, A, (CH2)n COOR19 and substituted (CH2)n COOR19.
Inventors:
James Robert Henry
Lee Hong
Lee Hong
Application Number:
JP2003565956A
Publication Date:
June 09, 2005
Filing Date:
January 21, 2003
Export Citation:
Assignee:
ELI LILLY AND COMPANY
International Classes:
C07D317/68; A61K31/195; A61K31/36; A61P3/10; A61P43/00; C07C275/10; C07C275/24; C07C275/26; C07C275/28; C07C275/30; C07C275/34; C07C275/36; C07C275/38; C07D317/66; (IPC1-7): C07C275/10; A61K31/195; A61K31/36; A61P3/10; A61P43/00; C07C275/24; C07C275/26; C07C275/28; C07C275/30; C07C275/36; C07C275/38; C07D317/68
Attorney, Agent or Firm:
Kyousei Tamura
Hiromitsu Takayama
Minato Saito
Hiromitsu Takayama
Minato Saito