Title:
UREIDO DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5973558
Kind Code:
A
Abstract:
NEW MATERIAL:2-Ureido-4,5-dimethoxybenzoic acid amide shown by the formula I .
USE: Useful as an intermediate for synthesizing drugs. For example, useful as an intermediate for synthesizing a guinazoline antihypertensive.
PROCESS: 2-Amino-4,5-dimethoxybenzoic acid amide shown by the formula II is reacted with an alkali metal cyanate (e.g., sodium cyanate, potassium cyanate, etc.) in an acidic solvent such as acetic acid, hydrochloric acid, sulfuric acid, etc. at 0W100°C, preferably at 15W30°C for 30minW24hr to give a compound shown by the formula I . This compound is then treated with an alkali to give 2,4-dihydroxy-6,7-dimethoxyquinazoline.
Inventors:
FUKUMI HIROSHI
SAITOU FUJIO
SAITOU FUJIO
Application Number:
JP18270482A
Publication Date:
April 25, 1984
Filing Date:
October 20, 1982
Export Citation:
Assignee:
SANKYO CO
International Classes:
C07D239/96; C07C67/00; C07C239/00; C07C275/42; (IPC1-7): C07C127/19; C07D239/96
Attorney, Agent or Firm:
Shoji Kashide
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