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Patent Searching and Data


Title:
URETHANES AND UREAS INDUCING PRODUCTION OF CYTOKINE
Document Type and Number:
Japanese Patent JPH07179414
Kind Code:
A
Abstract:

PURPOSE: To provide a novel urethane and a novel urea which induce the production of a cytokine useful for the treatment of cancers, AIDS, aregerative anemia, myelodysplastic syndrome and infectious diseases, and for the enhancement of immune responses.

CONSTITUTION: There is provided a compound of the formula (wherein R1 is H, a 1-20C alkyl, a cycloalkyl, vinyl, acetylene, NH2, an aryl, an aralkyl, a monocyclic or bicyclic heterocyclic group or the like; Ra and R3 are each H, a 1-6C alkyl, an alkoxyalkyl, a cycloalkyl, an aryl, an aralkyl, vinyl, acetyl, a monocyclic or bicyclic heterocyclic group or the like; R2, Rb and Rc are each carboxy, a carboxy-lower-alkyl or carboxamide; X is O or N; and R4 is H or an amino protecting group) and a pharmaceutically permissible salt thereof, e.g. N-[N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy) carbonyl]-(R)-6-[(phenylmethoxy)carbonyl]-L-lysyl]-D-alanine phenylmethyl ester.


Inventors:
SEMIRAMISU AIRARUUKARAUSUCHIYA
SUCHIIBUN AARU SHIYOU
MIRA TEI DOU
JIEIMUZU JIEI GIBONZU JIYUNIA
Application Number:
JP1994000119532
Publication Date:
July 18, 1995
Filing Date:
May 09, 1994
Export Citation:
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Assignee:
AMERICAN CYANAMID CO
International Classes:
C07D263/06; A61K31/17; A61K31/27; A61K31/325; A61K38/05; A61P31/12; A61P31/18; A61P35/00; A61P37/04; A61P43/00; C07C237/22; C07C269/04; C07C271/22; C07C271/24; C07C273/18; C07C275/16; C07C275/26; C07K5/02; C07K5/06; C07K5/068; C07K5/072; A61K38/00; (IPC1-7): C07C271/22; A61K31/17; A61K31/27; C07C237/22; C07C269/04; C07C273/18; C07C275/16; C07D263/06
Attorney, Agent or Firm:
Heiyoshi Odashima