Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
URIDINE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS58140098
Kind Code:
A
Abstract:

NEW MATERIAL:A compound shown by the formulaI(R1 is H or acyl and R2 is 5W18C alkyl, alkenyl, ≥6C cycloalkyl, phenyl, or naphthyl, or R1 is 2W4C acyl and R2 is 5W18C alkyl, alkenyl, or R1 is ≥5C acyl and R2 is R'2-, R'2O- (R'2 is alkyl, alkenyl, phenyl, naphthyl, etc.)].

EXAMPLE: 5'-O-Acetyl-5-fluoro-6-methoxy-5,6-dihydrouridine.

USE: An antitumor agent.

PROCESS: A compound shown by the formula II is reacted with fluorine in an element state or hyprofluorite shown by the formula RfOF(Rf is perfluoroalkyl) in the presence of an organic acid shown by the formula, so that fluorine and an acyloxy R'2COOH group are introduced to the 5 position and 6 position respectively, and, if necessary, the acyloxy group at the 6 position is converted into an alkoxy group with an alcohol shown by the formula R'-OH.


Inventors:
TAKAHARA TAKAO
HISANAGA YORISATO
KOUNO TOSHIHIKO
TANIKADO MUTSUMI
Application Number:
JP1982000012205
Publication Date:
August 19, 1983
Filing Date:
January 27, 1982
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
DAIKIN IND LTD
International Classes:
C07H19/067; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7072; A61P35/00; C07H19/06; (IPC1-7): A61K31/70; C07H19/06
Domestic Patent References:
JPS54144387A1979-11-10
JPS53147081A1978-12-21
JPS5516583A1980-02-05