Title:
Urinary-tract-infection (UTI) vaccine
Document Type and Number:
Japanese Patent JP5905457
Kind Code:
B2
Abstract:
A engineered bacteriophage is herein described, displaying at its surface multiple copies of a polypeptide, which comprises a domain of the bacterial adhesion protein FimH fused with the coat protein pVIII. The domain is preferably the region 45-159aa of the mature protein FimH. The polypeptide beingantigenic, raises a desired immunological response, in particular against urinary tract infections (UTI) in a human or animal. The engineered bacteriophage is therefore suitable for the preparation of vaccinesfor therapy, diagnosis and/or prevention of urinary tract infections (UTI) in a human or animal.
Inventors:
Rita de Santis
Olga Minenkova
Olga Minenkova
Application Number:
JP2013517251A
Publication Date:
April 20, 2016
Filing Date:
June 28, 2011
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
C12N7/00; A61K35/76; A61K39/02; A61P13/02; A61P31/04; A61K39/00
Domestic Patent References:
| JP2003509020A |
Foreign References:
| CA2286301A1 |
Other References:
The Journal of Infectious Diseases, 2001, Vol.183, Suppl.1, pp.S84-S86
Trends in Biotechnology, 2006, Vol.24, No.5, pp.212-218
Gene, 1993, Vol.128, pp.85-88
Trends in Biotechnology, 2006, Vol.24, No.5, pp.212-218
Gene, 1993, Vol.128, pp.85-88
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
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