Title:
女性化乳房治療用の薬剤を製造する際の4-ヒドロキシタモキシフェンの使用
Document Type and Number:
Japanese Patent JP5069469
Kind Code:
B2
Abstract:
The present invention provides methods for treating and preventing gynecomastia by administering 4-hydroxy tamoxifen to a patient. When percutaneously administered to a patient's breasts, 4-hydroxy tamoxifen concentrates locally, and exerts an anti-estrogenic effect. In patients with gynecomastia, this reduces the effective estrogen-androgen ratio in the breast tissue, thereby reducing ductal proliferation, epithelial and stromal hyperplasia, and pain. In patients at risk for developing gynecomastia, 4-hydroxy tamoxifen's anti-estrogenic effect prevents tissue proliferation and its accompanying pain.
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Inventors:
Renestur Elisabeth
Parumbo Andrew Earl.
Parumbo Andrew Earl.
Application Number:
JP2006543519A
Publication Date:
November 07, 2012
Filing Date:
December 13, 2004
Export Citation:
Assignee:
LABOR ATOILE Bezan INTERNATION
Ascend Therapeutics, Inc.
Ascend Therapeutics, Inc.
International Classes:
A61K31/138; A61K9/00; A61K9/06; A61K47/02; A61K47/04; A61K47/10; A61K47/14; A61K47/16; A61K47/18; A61K47/32; A61K47/38; A61P5/32; A61P15/00
Domestic Patent References:
| JP61500914A |
Other References:
北澤光孝,女性化乳房(gynecomastia),医薬ジャーナル,1994年,Vol.30,No.10,p161-165
阪村友美,脂肪酸エステル・アルコール・水基剤の経皮吸収促進効果,Therapeutic Research,1994年10月20日,第15巻第10号,第65-66頁
阪村友美,脂肪酸エステル・アルコール・水基剤の経皮吸収促進効果,Therapeutic Research,1994年10月20日,第15巻第10号,第65-66頁
Attorney, Agent or Firm:
Masayuki Masabayashi