Title:
癌の処置のための5,10-メチレンテトラヒドロ葉酸の使用
Document Type and Number:
Japanese Patent JP2007531728
Kind Code:
A
Abstract:
The present invention provides novel uses and compositions for 5,10-methylene tetrahydrofolate ("5,10-CH2-THFA") in the treatment of cancer. The present invention is based on the surprising result that 5,10-CH2-THFA, while increasing the efficacy of 5-fluoruracil (5-FU) in reducing the rate of tumor growth and increasing survivorship, also reduces the toxicity to the patient of 5-FU. The present invention provides methods and compositions for treating cancer patients that include 5-FU, 5,10-CH2-THFA, and one or more additional anticancer drugs. Such methods and compositions can provide increased efficacy and reduced toxicity when compared with current treatment modalities.
Inventors:
Robins, Joan Em.
Cantwell, Mark Jay.
Cantwell, Mark Jay.
Application Number:
JP2007506303A
Publication Date:
November 08, 2007
Filing Date:
April 01, 2005
Export Citation:
Assignee:
Adventorx Pharmaceuticals, Incorporated
International Classes:
A61K31/525; A61K31/00; A61K31/282; A61K31/337; A61K31/407; A61K31/4745; A61K31/475; A61K31/505; A61K31/513; A61K31/675; A61K31/704; A61K31/7068; A61K31/7088; A61K33/24; A61K39/395; A61K45/00; A61K45/06; A61P35/00; A61P43/00
Foreign References:
| US5534519A | 1996-07-09 | |||
| WO2002070008A1 | 2002-09-12 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita