ＡＮＰ３２蛋白質の宿主体内でのインフルエンザウィルスポリメラーゼ活性の維持への使用

Japanese Patent JP7189224

B2

The present invention provides a recombinant sequence information of a key host factor ANP32A/B which is necessary for the replication of influenza virus in a host. More specifically, the present invention relates to a 129-130 motif and a 149 site of the host factor ANP32A/B protein, which are key active sites for exerting its ability to promote the replication of influenza virus, and are also potential targeting sites of anti-influenza drugs.

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王 ▲曉▼▲鈞▼
▲張▼ ▲海▼▲麗▼
▲張▼ 振宇

JP2020542488A

December 13, 2022

February 26, 2019

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中国▲農▼▲業▼科学院哈▲爾▼▲濱▼▲獣▼医研究所（中国▲動▼物▲衛▼生▲与▼流行病学中心哈▲爾▼▲濱▼分中心）

C12N15/12; A01K67/027; C07K14/47; C12N9/16; C12Q1/44; C12Q1/6876

DOMINGUES, Patricia et al.,Cell Reports,2017年09月12日,Vol. 20,pp. 2538-2546
LONG, Jason S. et al.,NATURE,2016年01月07日,Vol. 529,pp. 101-104
WATANABE, Tokiko et al.,Cell Host & Microbe,2014年12月10日,Vol. 16,pp. 795-805

Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe

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