Title:
ヒトの子宮平滑筋腫の治療および診断におけるCYR61の使用
Document Type and Number:
Japanese Patent JP2004509909
Kind Code:
A
Abstract:
The present invention relates to methods of inhibiting uterine leiomyoma proliferation and preventing formation of uterine leiomyomas, compounds and compositions that stimulate induction of the Cyr61 gene and compounds that increase Cyr61 activity. The present invention also relates to methods of screening ligands that regulate Cyr61 protein expression. The invention further relates to methods of diagnosing patients with uterine leiomyomas associated with a downregulation of Cyr61 expression. The invention also describes antibodies and related pharmaceutical compositions.
More Like This:
Inventors:
Jimin Jiang
Deepak Sampass
Ju Yuan
Richard Winneker
Deepak Sampass
Ju Yuan
Richard Winneker
Application Number:
JP2002530024A
Publication Date:
April 02, 2004
Filing Date:
September 28, 2001
Export Citation:
Assignee:
Wyeth
International Classes:
A01K67/027; A61K31/7036; A61K31/7088; A61K38/00; A61K38/18; A61K38/22; A61K39/395; A61K45/00; A61K48/00; A61K49/00; A61P15/00; A61P35/00; C07K16/18; C07K16/22; C07K16/46; C12N15/09; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/68; (IPC1-7): A61K45/00; A01K67/027; A61K31/7088; A61K38/00; A61K38/22; A61K39/395; A61K48/00; A61P15/00; A61P35/00; C07K16/18; C07K16/46; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/68
Attorney, Agent or Firm:
Aoyama Aoi
Osamu Kawamiya
Mitsuo Tanaka
Osamu Kawamiya
Mitsuo Tanaka