Title:
Ｐ１Ｐ誘導体の敗血症の治療剤用途
Document Type and Number:
Japanese Patent JP7222566
Kind Code:
B2
Abstract:
The present disclosure provides a pharmaceutical composition for preventing or treating sepsis or septic shock comprising P1P or a derivative thereof. The present composition improves the survival rate of mice with sepsis induced by LPS or CLP treatment, as well as reduces the secretion of cytokines. Further, it helps to enhance the proliferation and function of vascular endothelial cells and increases the expression of SIRT1 protein which decreases in a sepsis patient. Accordingly, it can be effectively used in the treatment of sepsis.
Inventors:
Lee, Jung Min
Kim, Sujin
Han, Won Kyo
Park, Yong Jun
Choi, Myeong Jun
Kim, Sujin
Han, Won Kyo
Park, Yong Jun
Choi, Myeong Jun
Application Number:
JP2021544781A
Publication Date:
February 15, 2023
Filing Date:
January 29, 2020
Export Citation:
Assignee:
Exeso Biopharma Company Limited
International Classes:
A61K31/661; A61K9/10; A61K9/107; A61K9/127; A61P29/00; A61P31/04; A61P43/00
Foreign References:
| KR1020180032540A | ||||
| KR101003532B1 | ||||
| KR101340556B1 | ||||
| KR101514970B1 | ||||
| KR1020170063898A |
Other References:
集中治療医学領域における基礎研究最近のトピックス 炎症と脂質メディエーター,ICUとCCU,2018年,Vol.42, no.1,p.9-16
Modulation of human endothelial cell permeability by combinations of the cytokines interleukin-1 α/β, tumor necrosis factor-α and interferon-γ,Immunopharmacology,1993年,vol.25, no.11,p.1-9
Tumor Necrosis Factor α-induced Vascular Leakage Involves PECAM1 Phosphorylation,Cancer Research,1996年,Vol.56, no.14,p.3211-3215
Modulation of human endothelial cell permeability by combinations of the cytokines interleukin-1 α/β, tumor necrosis factor-α and interferon-γ,Immunopharmacology,1993年,vol.25, no.11,p.1-9
Tumor Necrosis Factor α-induced Vascular Leakage Involves PECAM1 Phosphorylation,Cancer Research,1996年,Vol.56, no.14,p.3211-3215
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK
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