eIF-5A1の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はsiRNAの使用

Japanese Patent JP5566250

B2

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.

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Taylor, catherine
Thompson, John Yee.
Gorton, Bruce Sea.
Krish, Dominique
Elizabeth Margaret, Heikkila
Senkaina, Diane Michelle
Flanagan, Joan Gerald

JP2010229103A

August 06, 2014

October 08, 2010

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Senesco Technologies, Inc.

A61K31/713; A61P1/16; A61P3/10; A61P9/04; A61P9/10; A61P11/06; A61P13/12; A61P17/02; A61P17/04; A61P19/02; A61P19/10; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/18; A61P37/02; A61P37/06; C07K14/435; C12N15/09; C12N15/113

JP2006520611A

WO2003010286A2

Database GenBank, Accession no.NM_020390, 09-Jan-2003 uploaded,URL,http://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?27552762:OLD03:2767922
Database GenBank, Accession no.NM_001970, 08-Apr-2002 uploaded,URL,http://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?20070167:OLD03:2742372
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J Neuroscience, vol.20, p.8693-8700 (2000)

Ikeda adult
Kazuhiro Yamaguchi
Masakazu Noda

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